TB-500 is a synthetic seven-residue peptide, Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln, corresponding to residues 17 to 23 of thymosin beta-4. This segment carries the actin-binding motif of the parent protein and reproduces much of its activity in cell-based research at a fraction of the molecular weight.
Research Applications
Laboratory research with TB-500 focuses on G-actin sequestration and cytoskeletal dynamics, cell migration and wound-closure assays, angiogenesis and endothelial cell models, and comparative studies against full-length thymosin beta-4.
Product Specifications
- Quantity: 5mg per vial
- Form: Lyophilized powder
- Purity: ≥99% (HPLC verified)
- Sequence: Ac-LKKTETQ (7 amino acids, Tβ4 17-23)
- Molecular weight: ≈889.0 Da
- Storage: Store at -20°C. Reconstituted solution stable at 2-8°C for up to 14 days.
- CAS Number: 885340-08-9
Note: This product is the acetylated 7-residue fragment (CAS 885340-08-9, MW ≈889 Da), not full-length thymosin beta-4 (CAS 77591-33-4, MW ≈4963 Da). The two are frequently sold interchangeably under the TB-500 name.
⚠️ For laboratory and research use only. Not intended for human or veterinary use.
